反应详情

In 130 ml of acetic anhydride was dissolved 8.6 g of 2-(tetrazol-5-yl)-5-bromopyridine prepared in the Preparation example 6. And then the solution was added with 15 ml of pyridine and stirred for 3 hours for reaction. The reaction mixture was added with ethyl acetate and extracted to separate organic layer. And then the organic layer was washed with water and brine. The organic layer was dehydrated, filtrated and concentrated in vacuo to give 7.3 g of the title compound. Yield 80%.

1. customprepared in the Preparation example 6
2. extractionextracted
3. customto separate organic layer
4. washAnd then the organic layer was washed with water and brine
5. filtrationfiltrated
6. concentrationconcentrated in vacuo