(5-Chloropyridin-2-yl)acetic acid → HCID 118341235, compound

HRID 1753009Notes

Reaction equation

HRID 1753009 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([OH:11])=O)=[N:6][CH:7]=1.[NH2:12][C:13]1[CH:14]=[C:15]([C:19]([C:21]2[C:25]3[CH:26]=[N:27][CH:28]=[C:29]([F:30])[C:24]=3[N:23]([CH:31]([CH3:34])[CH2:32][OH:33])[CH:22]=2)=[O:20])[CH:16]=[N:17][CH:18]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([NH:12][C:13]2[CH:18]=[N:17][CH:16]=[C:15]([C:19]([C:21]3[C:25]4[CH:26]=[N:27][CH:28]=[C:29]([F:30])[C:24]=4[N:23]([CH:31]([CH3:34])[CH2:32][OH:33])[CH:22]=3)=[O:20])[CH:14]=2)=[O:11])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 46737473(5-Chloropyridin-2-yl)acetic acidHCID 90093760HCID 90093760, compound

Product 1

HCID 118341235HCID 118341235, compound

Procedure

Prepared according to Method M (Example 206) using (5-chloropyridin-2-yl)acetic acid (Preparation 80) and (5-aminopyridin-3-yl)[7-fluoro-1-(2-hydroxy-1-methylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]methanone (Enantiomer 2, Preparation 26). The residue was purified using preparative TLC eluting with 5% MeOH in EtOAc.

Workup

  1. customPrepared
  2. customThe residue was purified
  3. washeluting with 5% MeOH in EtOAc

Sources & evidence

ORD record
ord-16644342c7574a4fbb2412dad0d4a3b7
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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