2-[4-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid → HCID 118341208, compound

HRID 1753011Notes

Reaction equation

HRID 1753011 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[N:5][N:6]([CH2:8][C:9]([OH:11])=O)[CH:7]=1.[NH2:14][C:15]1[CH:16]=[C:17]([C:21]([C:23]2[C:27]3[CH:28]=[N:29][CH:30]=[C:31]([F:32])[C:26]=3[N:25]([CH:33]([CH3:36])[CH2:34][OH:35])[CH:24]=2)=[O:22])[CH:18]=[N:19][CH:20]=1>>[F:32][C:31]1[C:26]2[N:25]([CH:33]([CH3:36])[CH2:34][OH:35])[CH:24]=[C:23]([C:21]([C:17]3[CH:16]=[C:15]([NH:14][C:9](=[O:11])[CH2:8][N:6]4[CH:7]=[C:3]([C:2]([F:1])([F:13])[F:12])[CH:4]=[N:5]4)[CH:20]=[N:19][CH:18]=3)=[O:22])[C:27]=2[CH:28]=[N:29][CH:30]=1

Participants

3

Reactant 2

HCID 641764822-[4-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acidHCID 90093760HCID 90093760, compound

Product 1

HCID 118341208HCID 118341208, compound

Procedure

Prepared according to Method M (Example 206) using [4-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (Preparation 74) and (5-aminopyridin-3-yl)[7-fluoro-1-(2-hydroxy-1-methylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]methanone (Enantiomer 2, Preparation 26). The residue was purified using preparative TLC eluting with 5% MeOH in EtOAc. LCMS (5 minute run) Rt=2.85 minutes MS m/z 491 [M+H]+

Workup

  1. customPrepared
  2. customThe residue was purified
  3. washeluting with 5% MeOH in EtOAc
  4. customLCMS (5 minute run) Rt=2.85 minutes MS m/z 491

Sources & evidence

ORD record
ord-5749e936a62a46e0b80de30a2c772007
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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