Sodium Carbonate → HCID 58993186, compound

4-Bromopyridine hydrochloride (1.1 g, 5.7 mmol) was treated with 5% Na2CO3 (aq, 35 mL) and the solution extracted with CH2Cl2 (3×15 mL). The extracts were combined, dried (Na2SO4), filtered and concentrated in vacuo to yield a oil. The oil was dried under high vacuum before the flask was flushed with nitrogen and then immediately dissolved in dry THF (15 mL). To this solution was added isopropylmagnesium chloride (2.6 M solution in ether, 2.2 mL, 5.7 mmol) dropwise under nitrogen. The resulting dark solution was stirred at room temperature for 1.5 h during which time a precipitate formed. Meanwhile, to a chilled (ice/acetone bath) suspension of tert-butyl {2-[methoxy(methyl)amino]-2-oxoethyl}carbamate (1.0 g, 4.6 mmol) in THF (10 mL) was added isopropylmagnesium chloride (2.6 M solution in ether, 1.8 mL, 4.7 mmol) dropwise. The resulting solution was stirred for 10 minutes before being added to the aryl Grignard initially generated. The mixture was stirred at room temperature overnight, diluted with water (25 mL) and brine (25 mL) and extracted with ethyl acetate (3×35 mL). The organic layers were dried (MgSO4), filtered and concentrated in vacuo to yield a yellow residue. The material was purified by flash chromatography (Biotage SP4, 40 g cartridge, 1 gradient CV hexanes, 0-100% EtOAc in hexanes 10 CV, hold for 5 CV) to give tert-butyl [2-oxo-2-(pyridin-4-yl)ethyl]carbamate as a yellow oil (785 mg yield 52%). 1H-NMR (400 MHz, CDCl3): δ 1.47 (s, 9H), 4.65 (d, 2H, J 4.6 Hz), 7.71-7.74 (m, 2H), 8.83-8.86 (m, 2H).

1. extractionthe solution extracted with CH2Cl2 (3×15 mL)
2. dry with materialdried (Na2SO4)
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customto yield a oil
6. customThe oil was dried under high vacuum before the flask
7. customwas flushed with nitrogen
8. dissolutionimmediately dissolved in dry THF (15 mL)
9. customformed
10. temperatureMeanwhile, to a chilled
11. stirringThe resulting solution was stirred for 10 minutes
12. stirringThe mixture was stirred at room temperature overnight
13. extractionextracted with ethyl acetate (3×35 mL)
14. dry with materialThe organic layers were dried (MgSO4)
15. filtrationfiltered
16. concentrationconcentrated in vacuo
17. customto yield a yellow residue
18. customThe material was purified by flash chromatography (Biotage SP4, 40 g cartridge, 1 gradient CV hexanes, 0-100% EtOAc in hexanes 10 CV, hold for 5 CV)

ORD record

ord-d693735bb6a34665a840055b17e16fef

Source dataset

uspto-grants-2015_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09163029B2