HCID 67371898, compound → HCID 67366244, compound

HRID 1753199Notes

Reaction equation

HRID 1753199 reaction equation
C(OC([NH:8][N:9]([C:21](=[CH:27][C:28]([O:30]CC)=O)[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1)=[O:12])=O)(C)(C)C>C1(C)C=CC=CC=1>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([C:11](=[O:12])[CH2:10][N:9]2[C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:27][C:28](=[O:30])[NH:8]2)=[CH:14][CH:15]=1

Participants

3

Reactant 1

HCID 67371898HCID 67371898, compound

Product 1

HCID 67366244HCID 67366244, compoundYield 91.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
85 °C

Procedure

A solution of crude diethyl 2-{2-(tert-butoxycarbonyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]hydrazinyl}but-2-enedioate (1.3 g) in toluene was added to polyphosphoric acid at 85° C. The reaction was heated at 85° C. for 1 hour after which time it was worked-up to give crude ethyl 2-[2-(4-methoxyphenyl)-2-oxoethyl]-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate (800 mg). ESI-MI m/z [M+H]+ 305.3.

Sources & evidence

ORD record
ord-2a3bcd553fa84d5a950e359f660615cc
Source dataset
uspto-grants-2015_10
Patent number
US09163029B2

Reaction notes

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