HCID 67371898, compound → HCID 67366244, compound

Participants

Reaction Conditions

Reaction Steps

A solution of crude diethyl 2-{2-(tert-butoxycarbonyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]hydrazinyl}but-2-enedioate (1.3 g) in toluene was added to polyphosphoric acid at 85° C. The reaction was heated at 85° C. for 1 hour after which time it was worked-up to give crude ethyl 2-[2-(4-methoxyphenyl)-2-oxoethyl]-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate (800 mg). ESI-MI m/z [M+H]+ 305.3.

Provenance & Evidence