反应详情

In 100 g of acetic acid was dissolved 15 g of (4-hexyloxyphenyl) phenyl sulfide obtained in Synthesis Example 1-21. While the solution was maintained at an internal temperature of 30° C., 5.1 g of 35 wt % aqueous hydrogen peroxide was added dropwise. The reaction solution was aged at room temperature for 18 hours, after which under ice cooling, a mixture of 1.3 g sodium thiosulfate pentahydrate and 15 g water was added dropwise to quench the reaction. The solution was combined with 100 g of methylene chloride and 20 g of water for extraction. The organic layer was separated, washed with water, and concentrated in vacuum, obtaining 14 g of the target compound, (4-hexyloxyphenyl) phenyl sulfoxide as amorphous solid. Yield 95%.

1. customobtained in Synthesis Example 1-21
2. additionwas added dropwise
3. additionwas added dropwise
4. customto quench
5. customthe reaction
6. extractionThe solution was combined with 100 g of methylene chloride and 20 g of water for extraction
7. customThe organic layer was separated
8. washwashed with water
9. concentrationconcentrated in vacuum