反应详情

In 85 g of acetic acid was dissolved 12 g of 4-(2-methoxyethoxy)phenyl phenyl sulfide obtained in Synthesis Example 1-29. While the solution was maintained at an internal temperature of 30° C., 4.5 g of 35 wt % aqueous hydrogen peroxide was added dropwise. The reaction solution was aged at room temperature for 18 hours, after which under ice cooling, a mixture of 1.2 g sodium thiosulfate pentahydrate and 15 g water was added dropwise to quench the reaction. The solution was combined with 80 g of methylene chloride and 40 g of water for extraction. The organic layer was separated, washed with water, and concentrated in vacuum. On subsequent crystallization from ethyl acetate/hexane, 11 g of the target compound, 4-(2-methoxyethoxy)phenyl phenyl sulfoxide was obtained as white crystals. Yield 86%.

1. customobtained in Synthesis Example 1-29
2. additionwas added dropwise
3. additionwas added dropwise
4. customto quench
5. customthe reaction
6. extractionThe solution was combined with 80 g of methylene chloride and 40 g of water for extraction
7. customThe organic layer was separated
8. washwashed with water
9. concentrationconcentrated in vacuum
10. customOn subsequent crystallization from ethyl acetate/hexane, 11 g of the target compound