Benzyl Bromide → HCID 9882402, compound

HRID 1753756Notes

Reaction equation

HRID 1753756 reaction equation
[CH3:1][C:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[C:10]([OH:15])[CH:11]=3)[C:6]=2[CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH3:1][C:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[C:10]([O:15][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH:11]=3)[C:6]=2[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 7498Benzyl BromideHCID 10796Cesium carbonateHCID 178432657HCID 178432657, compound

Product 1

HCID 9882402HCID 9882402, compoundYield 70%

Procedure

The title compound was synthesized from 1-methyl-7-hydroxy-β-carboline (0.500 g, 1.59 mmol) in presence of cesium carbonate (1.410 g, 4.33 mmol) and 1-bromomethylbenzene (0.432 g, 2.53 mmol) as described here above.

Sources & evidence

ORD record
ord-5e7991b035be45439ab7b27357a14112
Source dataset
uspto-grants-2015_10
Patent number
US09168247B2

Reaction notes

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