HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1753790Generated: October 28, 2026
Piperidine → 4-Chloro-6-piperidin-1-ylpyrimidine
https://huagongshe.com/reaction/1753790
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Chloro-6-piperidin-1-ylpyrimidine | HCID 597870 | — |
Reaction Steps
A mixture of 10.0 g (67.1 mmol) 4,6-dichloropyrimidine and 5.7 g (67.1 mmol) piperidine in 100 ml water is stirred at a bath temperature of 115° C. for 16 h. After cooling to RT, the precipitate is filtered off, washed with water and dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09168249B2 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-4506a753927842099d1c5fc1ef8c5df8 |
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| Source note | uspto-grants-2015_10 |
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