Piperidine → 4-Chloro-6-piperidin-1-ylpyrimidine

HRID 1753790Notes

Reaction equation

HRID 1753790 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>O>[Cl:8][C:6]1[CH:7]=[C:2]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:3]=[CH:4][N:5]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 709434,6-Dichloropyrimidine

Product 1

HCID 5978704-Chloro-6-piperidin-1-ylpyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
115 °C

Procedure

A mixture of 10.0 g (67.1 mmol) 4,6-dichloropyrimidine and 5.7 g (67.1 mmol) piperidine in 100 ml water is stirred at a bath temperature of 115° C. for 16 h. After cooling to RT, the precipitate is filtered off, washed with water and dried in vacuo.

Workup

  1. temperatureAfter cooling to RT
  2. filtrationthe precipitate is filtered off
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-4506a753927842099d1c5fc1ef8c5df8
Source dataset
uspto-grants-2015_10
Patent number
US09168249B2

Reaction notes

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