Hydrochloric Acid → HCID 67456835, compound

HRID 1753842Notes

Reaction equation

HRID 1753842 reaction equation
FC(F)(F)C(O)=O.[OH:8][CH:9]1[CH2:12][N:11]([C:13]2[N:18]=[CH:17][N:16]=[C:15]([N:19]3[C:23](=[O:24])[C:22]([N:25]4[CH:29]=[CH:28][N:27]=[CH:26]4)=[CH:21][NH:20]3)[CH:14]=2)[CH2:10]1.[ClH:30]>O1CCOCC1>[ClH:30].[OH:8][CH:9]1[CH2:10][N:11]([C:13]2[N:18]=[CH:17][N:16]=[C:15]([N:19]3[C:23](=[O:24])[C:22]([N:25]4[CH:29]=[CH:28][N:27]=[CH:26]4)=[CH:21][NH:20]3)[CH:14]=2)[CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68754491HCID 68754491, compound

Product 1

HCID 67456835HCID 67456835, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

100 mg (0.2 mmol) of the compound from Example 100 are stirred with 3 ml of a 4 N solution of hydrogen chloride in dioxane The solid is filtered off, washed twice with tert-butyl methyl ether and dried under a high vacuum.

Workup

  1. filtrationis filtered off
  2. washwashed twice with tert-butyl methyl ether
  3. customdried under a high vacuum

Sources & evidence

ORD record
ord-8d0b15e9f71a43eba356259ad8f9d4f2
Source dataset
uspto-grants-2015_10
Patent number
US09168249B2

Reaction notes

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