Hydrochloric Acid → 2-[6-(Ethylsulfanyl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

HRID 1753844Notes

Reaction equation

HRID 1753844 reaction equation
[CH2:1]([S:3][C:4]1[N:9]=[CH:8][N:7]=[C:6]([N:10]2[C:14](=[O:15])[C:13]([N:16]3[CH:20]=[CH:19][N:18]=[N:17]3)=[CH:12][NH:11]2)[CH:5]=1)[CH3:2].[ClH:21]>O1CCOCC1>[ClH:21].[CH2:1]([S:3][C:4]1[N:9]=[CH:8][N:7]=[C:6]([N:10]2[C:14](=[O:15])[C:13]([N:16]3[CH:20]=[CH:19][N:18]=[N:17]3)=[CH:12][NH:11]2)[CH:5]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 596035552-[6-(Ethylsulfanyl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one

Product 1

HCID 674569902-[6-(Ethylsulfanyl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

35 mg (0.1 mmol) of the compound from Example 102 are stirred with 1.5 ml of a 4 N solution of hydrogen chloride in dioxane. The solid is filtered off, washed twice with tert-butyl methyl ether and dried under a high vacuum.

Workup

  1. filtrationThe solid is filtered off
  2. washwashed twice with tert-butyl methyl ether
  3. customdried under a high vacuum

Sources & evidence

ORD record
ord-1b7e13c8175547b9bb133a03c83b1d29
Source dataset
uspto-grants-2015_10
Patent number
US09168249B2

Reaction notes

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