Ammonia → 3-Bromo-4,5-dihydro-1,2-oxazole-5-carboxamide

HRID 1753977Notes

Reaction equation

HRID 1753977 reaction equation
[Br:1][C:2]1[CH2:6][CH:5]([C:7]([O:9]CC)=O)[O:4][N:3]=1.[NH3:12]>CO>[Br:1][C:2]1[CH2:6][CH:5]([C:7]([NH2:12])=[O:9])[O:4][N:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 66696825Ethyl 3-bromo-4,5-dihydro-1,2-oxazole-5-carboxylate

Product 1

HCID 441183083-Bromo-4,5-dihydro-1,2-oxazole-5-carboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of ethyl 3-bromo-4,5-dihydroisoxazole-5-carboxylate (6.2 g, 28 mmol) and a solution of 2 M ammonia in MeOH (56 mL) was stirred at room temperature for 1 to 2 hours. Volatile materials were removed in vacuo to give the crude title compound as a white solid.

Workup

  1. customVolatile materials were removed in vacuo

Sources & evidence

ORD record
ord-d011d876bc284934b51899a00d1ca052
Source dataset
uspto-grants-2015_10
Patent number
US09168248B2

Reaction notes

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