HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Bromo-4,5-dihydro-1,2-oxazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl 3-bromo-4,5-dihydro-1,2-oxazole-5-carboxylate | HCID 66696825 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Bromo-4,5-dihydro-1,2-oxazole-5-carboxamide | HCID 44118308 | — |
Reaction Steps
A mixture of ethyl 3-bromo-4,5-dihydroisoxazole-5-carboxylate (6.2 g, 28 mmol) and a solution of 2 M ammonia in MeOH (56 mL) was stirred at room temperature for 1 to 2 hours. Volatile materials were removed in vacuo to give the crude title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09168248B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-d011d876bc284934b51899a00d1ca052 |
| Source note | uspto-grants-2015_10 |