反应详情

The above-described method (Example 2) was repeated to react benzyl 2-amino-5-bromo-3-methylbenzoate (3.00 g, 7.38 mmol) with copper cyanide (0.772 g, 7.98 mmol) in N-methylpyrrolidone at 170° C. for 6 hours. Following working up similar to Example 2, additional extraction with ethyl acetate, washing with aqueous 5% ethylenediamine solution and column chromatography, benzyl 2-amino-5-cyano-3-methylbenzoate (1.00 g, 47.9% of theory, 97.0 area % LC) was obtained as a pale brown solid.

1. extractionFollowing working up similar to Example 2, additional extraction with ethyl acetate
2. washwashing with aqueous 5% ethylenediamine solution and column chromatography