反应详情

温度

27.5 °C

2-[4-(4-Chlorophenyl)cyclohexyl-3-chloro-1,4-naphthoquinone (20 gm) was added to methanol (400 ml) at 25-30° C., the contents were heated to reflux and then potassium hydroxide solution (20 gm) in water (200 ml) was slowly added for 30 minutes at reflux. The reaction mass was stirred for 6 hours at reflux, to the resulting mass added hydrochloric acid (72 ml) slowly for 15 to 20 minutes at reflux and then cooled to 25-30° C. The resulting mass was further cooled to 0° C. and then stirred for 1 hour at 0-5° C. The solid was filtered, washed with water and then dried at 50-60° C. to give 18.1 gm of atovaquone.

1. temperaturethe contents were heated
2. temperatureto reflux
3. temperatureat reflux
4. temperatureat reflux, to the resulting mass
5. temperatureat reflux
6. temperatureThe resulting mass was further cooled to 0° C.
7. stirringstirred for 1 hour at 0-5° C
8. filtrationThe solid was filtered
9. washwashed with water
10. customdried at 50-60° C.