Hydrochloric Acid → HCID 58479484, compound

HRID 1754232Notes

Reaction equation

HRID 1754232 reaction equation
C[O:2][C:3]1(OC)[CH:7]2[C:8]3[C:13]([CH:4]1[CH2:5][CH2:6]2)=[CH:12][CH:11]=[CH:10][C:9]=3[NH:14][C:15]([C:17]1[C:18]([CH:23]([F:25])[F:24])=[N:19][N:20]([CH3:22])[CH:21]=1)=[O:16].Cl.O>CC(C)=O>[O:2]=[C:3]1[CH:7]2[C:8]3[C:13]([CH:4]1[CH2:5][CH2:6]2)=[CH:12][CH:11]=[CH:10][C:9]=3[NH:14][C:15]([C:17]1[C:18]([CH:23]([F:25])[F:24])=[N:19][N:20]([CH3:22])[CH:21]=1)=[O:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 58479476HCID 58479476, compound

Product 1

HCID 58479484HCID 58479484, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
50 °C

Procedure

An oven-dried Schlenk was charged with compound 4 (100 mg, 0.26 mmol) and dissolved in acetone (1 mL). Hydrochloric acid was added (37%, 2 drops) and the mixture was stirred under nitrogen for 30 minutes at 50° C. GCMS analysis indicated compete conversion of starting material and water was added to mixture (5 mL). Extraction into ethyl acetate (3×5 mL) followed by concentration in vacuo affords compound 5 (quantitative conversion).

Workup

  1. extractionExtraction into ethyl acetate (3×5 mL)
  2. concentrationfollowed by concentration in vacuo

Sources & evidence

ORD record
ord-e026ed12c5634657839794336022a0a7
Source dataset
uspto-grants-2015_10
Patent number
US09169233B2

Reaction notes

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