Pyridine → HCID 58487346, compound

HRID 1754344Notes

Reaction equation

HRID 1754344 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][N:3]=1.[F:9][C:10]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:11]=1[C:12](Cl)=[O:13].N1C=CC=CC=1>C(Cl)Cl>[Br:1][C:2]1[N:3]=[CH:4][C:5]([NH:8][C:12](=[O:13])[C:11]2[C:10]([F:9])=[CH:18][CH:17]=[CH:16][C:15]=2[F:19])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 874382,6-Difluorobenzoyl chlorideHCID 6428116-Bromopyridin-3-amine

Product 1

HCID 58487346HCID 58487346, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To a (0° C.) cooled and stirred solution of 2-bromo-5-aminopyridine (2.0 g, 11.56 mmol, 1.0 eq) in DCM (25 mL) was added sequentially 2,6-difluorobenzoyl chloride (1.44 mL, 11.56 mmol, 1.0 eq) and pyridine (1.19 mL, 13.87 mmol, 1.2 eq). The resulting mixture was allowed to warm to room temperature and then stirred at the same temperature for 30 min.

Workup

  1. temperatureto warm to room temperature

Sources & evidence

ORD record
ord-867ae944b7f546da8f97217ceea4011a
Source dataset
uspto-grants-2015_10
Patent number
US09169242B2

Reaction notes

Loading…