Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2,6-Difluorobenzoyl chloride | HCID 87438 | — |
| Reactant | 6-Bromopyridin-3-amine | HCID 642811 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58487346 | HCID 58487346 | — |
Reaction Steps
To a (0° C.) cooled and stirred solution of 2-bromo-5-aminopyridine (2.0 g, 11.56 mmol, 1.0 eq) in DCM (25 mL) was added sequentially 2,6-difluorobenzoyl chloride (1.44 mL, 11.56 mmol, 1.0 eq) and pyridine (1.19 mL, 13.87 mmol, 1.2 eq). The resulting mixture was allowed to warm to room temperature and then stirred at the same temperature for 30 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09169242B2 |
|---|
| Source dataset | uspto-grants-2015_10 |
|---|
| ORD ID | ord-867ae944b7f546da8f97217ceea4011a |
|---|
| Source note | uspto-grants-2015_10 |
|---|
