4-Fluorobenzaldehyde → 1-(Bromomethyl)-4-(propane-2-sulfonyl)benzene

HRID 1754511Notes

Reaction equation

HRID 1754511 reaction equation
[Br:1]CC1C=CC(S(C)(=O)=O)=C(F)C=1.F[C:15]1[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=1.[Na+].[CH3:24][CH:25]([S:27]([O-:29])=[O:28])[CH3:26]>>[Br:1][CH2:19][C:18]1[CH:21]=[CH:22][C:15]([S:27]([CH:25]([CH3:26])[CH3:24])(=[O:29])=[O:28])=[CH:16][CH:17]=1

Participants

4

Reactant 3

HCID 680234-FluorobenzaldehydeHCID 23685748Sodium propane-2-sulfinateHCID 672190653-Fluoro-4-(methylsulphonyl)benzyl bromide

Product 1

HCID 672197581-(Bromomethyl)-4-(propane-2-sulfonyl)benzene

Procedure

The titled compound is prepared analogously to 4-bromomethyl-2-fluoro-1-methanesulfonyl-benzene by replacing 3,4-difluorobenzaldehyde with 4-fluorobenzaldehyde and by replacing methane sulfinic acid sodium salt with 2-propanesulfinic acid sodium salt.

Sources & evidence

ORD record
ord-f1ed964fb9f14c61ad22a936fdc66571
Source dataset
uspto-grants-2015_10
Patent number
US09169251B2

Reaction notes

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