4-Fluoro-3-methoxybenzenesulfonyl chloride → 6-Cyanopyridine-3-sulfonyl chloride

HRID 1754521Notes

Reaction equation

HRID 1754521 reaction equation
FC1C=CC([S:8]([Cl:11])(=[O:10])=[O:9])=CC=1OC.N[C:15]1[CH:16]=[CH:17][C:18]([C:21]#[N:22])=[N:19][CH:20]=1>>[C:21]([C:18]1[N:19]=[CH:20][C:15]([S:8]([Cl:11])(=[O:10])=[O:9])=[CH:16][CH:17]=1)#[N:22]

Participants

3

Reactant 2

HCID 27834084-Fluoro-3-methoxybenzenesulfonyl chloride2×HCID 38713955-Aminopyridine-2-carbonitrile

Product 1

HCID 470031906-Cyanopyridine-3-sulfonyl chloride

Procedure

The titled compound is prepared analogously to 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 5-amino-pyridine-2-carbonitrile.

Sources & evidence

ORD record
ord-68eaa0d3232e433498dcecae94ad0f03
Source dataset
uspto-grants-2015_10
Patent number
US09169251B2

Reaction notes

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