Benzonitrile, 2-amino-4-chloro- → 5-Chloro-2-cyanobenzene-1-sulfonyl chloride

HRID 1754526Notes

Reaction equation

HRID 1754526 reaction equation
FC1C=CC([S:8]([Cl:11])(=[O:10])=[O:9])=CC=1OC.N[C:15]1[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:16]=1[C:17]#[N:18]>>[Cl:23][C:21]1[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[C:15]([S:8]([Cl:11])(=[O:10])=[O:9])[CH:22]=1

Participants

3

Reactant 2

HCID 170059Benzonitrile, 2-amino-4-chloro-HCID 27834084-Fluoro-3-methoxybenzenesulfonyl chloride2×

Product 1

HCID 167925385-Chloro-2-cyanobenzene-1-sulfonyl chloride

Procedure

The titled compound is prepared analogously 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 2-amino-4-chloro-benzonitrile.

Sources & evidence

ORD record
ord-24c980b8c49e4f7b8b082669b772b662
Source dataset
uspto-grants-2015_10
Patent number
US09169251B2

Reaction notes

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