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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1754526Generated: October 28, 2026

Benzonitrile, 2-amino-4-chloro- → 5-Chloro-2-cyanobenzene-1-sulfonyl chloride

https://huagongshe.com/reaction/1754526

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzonitrile, 2-amino-4-chloro-HCID 170059—
Reactant4-Fluoro-3-methoxybenzenesulfonyl chlorideHCID 2783408—
Product5-Chloro-2-cyanobenzene-1-sulfonyl chlorideHCID 16792538—

Reaction Steps

The titled compound is prepared analogously 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 2-amino-4-chloro-benzonitrile.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09169251B2
Source datasetuspto-grants-2015_10
ORD IDord-24c980b8c49e4f7b8b082669b772b662
Source noteuspto-grants-2015_10