4-Chloro-3-fluoroaniline → 4-Chloro-3-fluorobenzene-1-sulfonyl chloride

HRID 1754530Notes

Reaction equation

HRID 1754530 reaction equation
FC1C=CC([S:8]([Cl:11])(=[O:10])=[O:9])=CC=1OC.[Cl:14][C:15]1[CH:20]=[CH:19][C:18](N)=[CH:17][C:16]=1[F:22]>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:8]([Cl:11])(=[O:10])=[O:9])=[CH:17][C:16]=1[F:22]

Participants

3

Reactant 2

HCID 27365114-Chloro-3-fluoroanilineHCID 27834084-Fluoro-3-methoxybenzenesulfonyl chloride2×

Product 1

HCID 435661924-Chloro-3-fluorobenzene-1-sulfonyl chloride

Procedure

The titled compound is prepared analogously to 4-fluoro-3-methoxy-benzenesulfonyl chloride (Intermediate 102a) by replacing 4-fluoro-3-methoxyaniline with 4-chloro-3-fluoro-phenylamine.

Sources & evidence

ORD record
ord-e50275ece1fa427f84480e2c76ed939c
Source dataset
uspto-grants-2015_10
Patent number
US09169251B2

Reaction notes

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