HCID 86712758, compound → HCID 86712759, compound

HRID 1754549Notes

Reaction equation

HRID 1754549 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4]1([CH2:15][CH2:14][CH2:13]1)[CH2:5][C:6](=O)[NH:7]2>O1CCCC1>[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4]1([CH2:15][CH2:14][CH2:13]1)[CH2:5][CH2:6][NH:7]2

Participants

3

Reactant 1

HCID 86712758HCID 86712758, compound

Product 1

HCID 86712759HCID 86712759, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 50 mg (0.244 mmol) of 5′-fluoro-1′H-spiro[cyclobutane-1,4′-quinolin]-2′(3′H)-one obtained in step 31.2 in 1 mL of tetrahydrofuran was treated with 0.73 mL of 1 M solution of borohydride-tetrahydrofuran complex in tetrahydrofuran. The mixture was stirred at reflux for 2 h, quenched with water and evaporated till dryness. The crude compound was used in the subsequent step without purification.

Workup

  1. temperatureat reflux for 2 h
  2. customquenched with water
  3. customevaporated till dryness
  4. customThe crude compound was used in the subsequent step without purification

Sources & evidence

ORD record
ord-d913e42422c84b0287060a3316811ac9
Source dataset
uspto-grants-2015_10
Patent number
US09169253B2

Reaction notes

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