Hydrochloric Acid → HCID 71535318, compound

HRID 1754552Notes

Reaction equation

HRID 1754552 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10]2[C:11]3[N:25](C4CCCCO4)[NH:24][CH2:23][C:12]=3[C:13](=[O:22])[N:14]([CH2:17][C:18]([F:21])([F:20])[F:19])[C:15]=2[CH:16]=1.N1C=CC=CC=1C1C=CC2C3C(=CN(C4CCCCO4)N=3)C(=O)N(CC(F)(F)F)C=2C=1.Cl.O1CCOCC1>C(Cl)Cl>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10]2[C:11]3[NH:25][N:24]=[CH:23][C:12]=3[C:13](=[O:22])[N:14]([CH2:17][C:18]([F:20])([F:19])[F:21])[C:15]=2[CH:16]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86679790HCID 86679790, compoundHCID 86679791HCID 86679791, compound

Product 1

HCID 71535318HCID 71535318, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 7-(pyrid-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one and 7-(pyrid-2-yl)-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one (60 mg, 0.14 mmol) in 1 mL of DCM is added a 4M solution of anhydrous hydrogen chloride in dioxane (350 μL, 1.40 mmol). After stirring for 1 hour at room temperature, the suspension is filtered and the solid is dried under vacuum to give 59 mg of 7-(pyrid-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one in the form of a beige-coloured powder (hydrochloride, 0.88 H2O; quantitative yield).

Workup

  1. filtrationthe suspension is filtered
  2. customthe solid is dried under vacuum

Sources & evidence

ORD record
ord-a1d5166802994d03995cb714053731d8
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

Loading…