Hydrochloric Acid → HCID 178479168, compound

HRID 1754571Notes

Reaction equation

HRID 1754571 reaction equation
[O:1]=[C:2]1[C:11]2[CH2:12][NH:13][N:14](COCC[Si](C)(C)C)[C:10]=2[C:9]2[CH:8]=[C:7]([C:23]#[N:24])[C:6]([C:25]3[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=3)=[CH:5][C:4]=2[N:3]1[CH2:31][C:32]([F:35])([F:34])[F:33].O=C1C2=CN(COCC[Si](C)(C)C)N=C2C2C=C(C#N)C(C3C=CN=CC=3)=CC=2N1CC(F)(F)F.[ClH:71]>>[ClH:71].[O:1]=[C:2]1[C:11]2=[CH:12][NH:13][N:14]=[C:10]2[C:9]2[CH:8]=[C:7]([C:23]#[N:24])[C:6]([C:25]3[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=3)=[CH:5][C:4]=2[N:3]1[CH2:31][C:32]([F:34])([F:35])[F:33]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 89454251HCID 89454251, compoundHCID 89454309HCID 89454309, compound

Product 1

HCID 178479168HCID 178479168, compoundYield 15%

Procedure

The product is obtained according to the procedure described in Step 4.3. starting with 4-oxo-7-(pyrid-4-yl)-5-(2,2,2-trifluoroethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline-8-carbonitrile and 4-oxo-7-(pyrid-4-yl)-5-(2,2,2-trifluoroethyl)-2-{[2-(trimethylsilyl)ethoxy]methyl}-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline-8-carbonitrile, in the form of a white powder (1.8 hydrochloride; yield 15%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-1297789001834c7d872a755376eb703a
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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