Hydrochloric Acid → HCID 89453976, compound

HRID 1754573Notes

Reaction equation

HRID 1754573 reaction equation
[N:1]1([C:7]([C:9]2[C:14]([C:15]3[CH:16]=[CH:17][C:18]4[C:19]5[N:33](C6CCCCO6)[N:32]=[CH:31][C:20]=5[C:21](=[O:30])[N:22]([CH2:25][C:26]([F:29])([F:28])[F:27])[C:23]=4[CH:24]=3)=[CH:13][CH:12]=[CH:11][N:10]=2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.N1(C(C2C(C3C=CC4C5NN(C6CCCCO6)CC=5C(=O)N(CC(F)(F)F)C=4C=3)=CC=CN=2)=O)CCOCC1.[ClH:79]>O>[ClH:79].[N:1]1([C:7]([C:9]2[C:14]([C:15]3[CH:16]=[CH:17][C:18]4[C:19]5[NH:33][N:32]=[CH:31][C:20]=5[C:21](=[O:30])[N:22]([CH2:25][C:26]([F:27])([F:29])[F:28])[C:23]=4[CH:24]=3)=[CH:13][CH:12]=[CH:11][N:10]=2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 89453934HCID 89453934, compoundHCID 89454321HCID 89454321, compound

Product 1

HCID 89453976HCID 89453976, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product is obtained according to the procedure described in Step 1.7. starting with 7-[2-(morpholin-4-ylcarbonyl)pyrid-3-yl]-1-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one and 7-[2-(morpholin-4-ylcarbonyl)pyrid-3-yl]-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one, in the form of a white powder (hydrochloride, 0.7 H2O; yield 78%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-81617f34616b4b6980d5078e6c5f73e3
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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