Hydrochloric Acid → HCID 89454124, compound

HRID 1754574Notes

Reaction equation

HRID 1754574 reaction equation
O=[C:2]1C2C=NN(C3CCCCO3)C=2C2C=CC(C3C(NC(=O)C)=NC=CC=3)=CC=2[N:3]1CC(F)(F)F.[O:36]=[C:37]1[C:46]2[CH2:47][N:48](C3CCCCO3)[NH:49][C:45]=2[C:44]2[CH:43]=[CH:42][C:41]([C:56]3[C:57]([NH:62][C:63](=[O:65])[CH3:64])=NC=[CH:60][CH:61]=3)=[CH:40][C:39]=2[N:38]1[CH2:66][C:67]([F:70])([F:69])[F:68].[ClH:71]>O>[ClH:71].[O:36]=[C:37]1[C:46]2[CH:47]=[N:48][NH:49][C:45]=2[C:44]2[CH:43]=[CH:42][C:41]([C:56]3[CH:61]=[CH:60][N:3]=[CH:2][C:57]=3[NH:62][C:63](=[O:65])[CH3:64])=[CH:40][C:39]=2[N:38]1[CH2:66][C:67]([F:68])([F:69])[F:70]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 89454135HCID 89454135, compoundHCID 89454208HCID 89454208, compound

Product 1

HCID 89454124HCID 89454124, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product is obtained according to the procedure described in Step 3.4. starting with N-{3-[4-oxo-1-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinolin-7-yl]pyrid-2-yl}acetamide and N-{3-[4-oxo-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinolin-7-yl]pyrid-2-yl}acetamide, in the form of a white powder (hydrochloride, 1.5 H2O; yield 66%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-c2a0c316d4e948a0a7dd33e647b00ba8
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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