Hydrochloric Acid → HCID 86730110, compound

HRID 1754576Notes

Reaction equation

HRID 1754576 reaction equation
[CH3:1][N:2]([C:6]1[C:11]([C:12]2[CH:13]=[CH:14][C:15]3[C:16]4[N:30](C5CCCCO5)[N:29]=[CH:28][C:17]=4[C:18](=[O:27])[N:19]([CH2:22][C:23]([F:26])([F:25])[F:24])[C:20]=3[CH:21]=2)=[CH:10][CH:9]=[CH:8][N:7]=1)[C:3](=[O:5])[CH3:4].CN(C1C(C2C=CC3C4NN(C5CCCCO5)CC=4C(=O)N(CC(F)(F)F)C=3C=2)=CC=CN=1)C(=O)C.[ClH:73]>O>[ClH:73].[CH3:1][N:2]([C:6]1[C:11]([C:12]2[CH:13]=[CH:14][C:15]3[C:16]4[NH:30][N:29]=[CH:28][C:17]=4[C:18](=[O:27])[N:19]([CH2:22][C:23]([F:26])([F:25])[F:24])[C:20]=3[CH:21]=2)=[CH:10][CH:9]=[CH:8][N:7]=1)[C:3](=[O:5])[CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 86730112HCID 86730112, compoundHCID 86730113HCID 86730113, compound

Product 1

HCID 86730110HCID 86730110, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product is obtained according to the procedure described in Step 1.7. starting with N-methyl-N-{3-[4-oxo-1-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinolin-7-yl]pyrid-2-yl}acetamide and N-methyl-N-{3-[4-oxo-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinolin-7-yl]pyrid-2-yl}acetamide, in the form of a white powder (hydrochloride, 1 H2O; yield 58%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-21f5e8da03fb46e497528f07d56f5a58
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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