Hydrochloric Acid → HCID 89453775, compound

HRID 1754577Notes

Reaction equation

HRID 1754577 reaction equation
[N:1]1([C:8]2[C:13]([C:14]3[CH:15]=[CH:16][C:17]4[C:18]5[N:32](C6CCCCO6)[N:31]=[CH:30][C:19]=5[C:20](=[O:29])[N:21]([CH2:24][C:25]([F:28])([F:27])[F:26])[C:22]=4[CH:23]=3)=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.N1(C2C(C3C=CC4C5NN(C6CCCCO6)CC=5C(=O)N(CC(F)(F)F)C=4C=3)=CC=CN=2)CCCNCC1.[ClH:77]>O>[ClH:77].[N:1]1([C:8]2[C:13]([C:14]3[CH:15]=[CH:16][C:17]4[C:18]5[NH:32][N:31]=[CH:30][C:19]=5[C:20](=[O:29])[N:21]([CH2:24][C:25]([F:27])([F:26])[F:28])[C:22]=4[CH:23]=3)=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 89454262HCID 89454262, compoundHCID 89454355HCID 89454355, compound

Product 1

HCID 89453775HCID 89453775, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product is obtained according to the procedure described in Step 1.7. starting with 7-[2-(1,4-diazepan-1-yl)pyrid-3-yl]-1-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one and 7-[2-(1,4-diazepan-1-yl)pyrid-3-yl]-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one, in the form of a white powder (hydrochloride, 1 H2O; yield 75%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-20af7825a8014a39b1a067c88f681381
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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