Hydrochloric Acid → HCID 89453891, compound

HRID 1754578Notes

Reaction equation

HRID 1754578 reaction equation
[N:1]1([C:7]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]4[C:17]5[N:31](C6CCCCO6)[N:30]=[CH:29][C:18]=5[C:19](=[O:28])[N:20]([CH2:23][C:24]([F:27])([F:26])[F:25])[C:21]=4[CH:22]=3)=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.N1(C2C(C3C=CC4C5NN(C6CCCCO6)CC=5C(=O)N(CC(F)(F)F)C=4C=3)=CC=CN=2)CCCCC1.[ClH:75]>O>[ClH:75].[N:1]1([C:7]2[C:12]([C:13]3[CH:14]=[CH:15][C:16]4[C:17]5[NH:31][N:30]=[CH:29][C:18]=5[C:19](=[O:28])[N:20]([CH2:23][C:24]([F:26])([F:25])[F:27])[C:21]=4[CH:22]=3)=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 89454177HCID 89454177, compoundHCID 89454312HCID 89454312, compound

Product 1

HCID 89453891HCID 89453891, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product is obtained according to the procedure described in Step 1.7. starting with 7-[2-(piperidin-1-yl)pyrid-3-yl]-1-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one and 7-[2-(piperidin-1-yl)pyrid-3-yl]-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one, in the form of a white powder (hydrochloride, 1.3 H2O; yield 86%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-03d29321e36445fea23d4f24caf478a9
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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