Hydrochloric Acid → HCID 86679814, compound

HRID 1754579Notes

Reaction equation

HRID 1754579 reaction equation
[CH:1]1([N:4]2[CH2:9][CH2:8][N:7]([C:10]3[C:15]([C:16]4[CH:17]=[CH:18][C:19]5[C:20]6[N:34](C7CCCCO7)[N:33]=[CH:32][C:21]=6[C:22](=[O:31])[N:23]([CH2:26][C:27]([F:30])([F:29])[F:28])[C:24]=5[CH:25]=4)=[CH:14][CH:13]=[CH:12][N:11]=3)[CH2:6][CH2:5]2)[CH2:3][CH2:2]1.C1(N2CCN(C3C(C4C=CC5C6NN(C7CCCCO7)CC=6C(=O)N(CC(F)(F)F)C=5C=4)=CC=CN=3)CC2)CC1.[ClH:81]>>[ClH:81].[CH:1]1([N:4]2[CH2:5][CH2:6][N:7]([C:10]3[C:15]([C:16]4[CH:17]=[CH:18][C:19]5[C:20]6[NH:34][N:33]=[CH:32][C:21]=6[C:22](=[O:31])[N:23]([CH2:26][C:27]([F:28])([F:29])[F:30])[C:24]=5[CH:25]=4)=[CH:14][CH:13]=[CH:12][N:11]=3)[CH2:8][CH2:9]2)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 86679816HCID 86679816, compoundHCID 86679817HCID 86679817, compound

Product 1

HCID 86679814HCID 86679814, compoundYield 70%

Procedure

The product is obtained according to the procedure described in Step 1.7. starting with 7-[2-(4-cyclopropylpiperazin-1-yl)pyrid-3-yl]-1-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one and 7-[2-(4-cyclopropyl-piperazin-1-yl)pyrid-3-yl]-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one, in the form of a white powder (3 hydrochloride, 3H2O; yield 70%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-2de83ae4ed054b2ba6a5900e3e6776c1
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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