Hydrochloric Acid → HCID 86679818, compound

HRID 1754580Notes

Reaction equation

HRID 1754580 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[C:14]([C:15]3[CH:16]=[CH:17][C:18]4[C:19]5[N:33](C6CCCCO6)[N:32]=[CH:31][C:20]=5[C:21](=[O:30])[N:22]([CH2:25][C:26]([F:29])([F:28])[F:27])[C:23]=4[CH:24]=3)=[CH:13][CH:12]=[CH:11][N:10]=2)[CH2:4][CH2:3]1.CN1CCCN(C2C(C3C=CC4C5NN(C6CCCCO6)CC=5C(=O)N(CC(F)(F)F)C=4C=3)=CC=CN=2)CC1.[ClH:79]>O>[ClH:79].[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]2[C:14]([C:15]3[CH:16]=[CH:17][C:18]4[C:19]5[NH:33][N:32]=[CH:31][C:20]=5[C:21](=[O:30])[N:22]([CH2:25][C:26]([F:28])([F:27])[F:29])[C:23]=4[CH:24]=3)=[CH:13][CH:12]=[CH:11][N:10]=2)[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 86679819HCID 86679819, compoundHCID 86679820HCID 86679820, compound

Product 1

HCID 86679818HCID 86679818, compoundYield 28%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product is obtained according to the procedure described in Step 1.7. starting with 7-[2-(4-methyl-1,4-diazepan-1-yl)pyrid-3-yl]-1-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one and 7-[2-(4-methyl-1,4-diazepan-1-yl)pyrid-3-yl]-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one, in the form of a white powder (2 hydrochloride, 5.5 H2O; yield: 28%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-b2c64eaf48f9442aa9e8070273e81db9
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

Loading…