Hydrochloric Acid → HCID 89454220, compound

HRID 1754581Notes

Reaction equation

HRID 1754581 reaction equation
O1CCCCC1N1C2C3C=CC=CC=3N(CC(F)(F)F)C(=O)C=2C=N1.[F:26][CH:27]1[CH2:31][CH2:30][N:29]([C:32]2[C:37]([C:38]3[CH:39]=[CH:40][C:41]4[C:42]5[NH:56][N:55](C6CCCCO6)[CH2:54][C:43]=5[C:44](=[O:53])[N:45]([CH2:48][C:49]([F:52])([F:51])[F:50])[C:46]=4[CH:47]=3)=[CH:36][CH:35]=[CH:34][N:33]=2)[CH2:28]1.[ClH:63]>O>[ClH:63].[F:26][CH:27]1[CH2:31][CH2:30][N:29]([C:32]2[C:37]([C:38]3[CH:39]=[CH:40][C:41]4[C:42]5[NH:56][N:55]=[CH:54][C:43]=5[C:44](=[O:53])[N:45]([CH2:48][C:49]([F:52])([F:51])[F:50])[C:46]=4[CH:47]=3)=[CH:36][CH:35]=[CH:34][N:33]=2)[CH2:28]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 89453703HCID 89453703, compoundHCID 131733669HCID 131733669, compound

Product 1

HCID 89454220HCID 89454220, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product is obtained according to the procedure described in Step 1.7. starting with 7-[2-(3-fluoropyrrolidin-1-yl)pyrid-3-yl]-1-(tetrahydro-2H-pyran-2-yl-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one and 7-[2-(3-fluoropyrrolidin-1-yl)pyrid-3-yl]-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one, in the form of a white powder (hydrochloride. H2O; yield 47%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-6fdf7358765d4b9b8fed54bf24c64252
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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