Hydrochloric Acid → HCID 178479610, compound

HRID 1754583Notes

Reaction equation

HRID 1754583 reaction equation
[O-:1][N+:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[CH:10][C:11]2[C:12]3[N:26](C4CCCCO4)[N:25]=[CH:24][C:13]=3[C:14](=[O:23])[N:15]([CH2:18][C:19]([F:22])([F:21])[F:20])[C:16]=2[CH:17]=1.[O-][N+]1C=CC=CC=1C1C=CC2C3NN(C4CCCCO4)CC=3C(=O)N(CC(F)(F)F)C=2C=1.[ClH:65].O>O1CCOCC1>[ClH:65].[O-:1][N+:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[CH:10][C:11]2[C:12]3[NH:26][N:25]=[CH:24][C:13]=3[C:14](=[O:23])[N:15]([CH2:18][C:19]([F:22])([F:20])[F:21])[C:16]=2[CH:17]=1

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 962WaterHCID 86730116HCID 86730116, compoundHCID 86730117HCID 86730117, compound

Product 1

HCID 178479610HCID 178479610, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product is obtained according to the procedure described in Step 1.7. by treating 7-(1-oxidopyrid-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one and 7-(1-oxidopyridin-2-yl)-2-(tetrahydro-2H-pyran-2-yl)-5-(2,2,2-trifluoroethyl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one with 4M HCl in dioxane, in the form of a white powder (hydrochloride, 1 H2O; yield 99%).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-51f324eb50764f13985bc10d8e52ba43
Source dataset
uspto-grants-2015_10
Patent number
US09169246B2

Reaction notes

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