HCID 57619279, compound → 5-amino-2-ethyl-2H-pyrazole-3-carboxylic acid methyl ester

HRID 1754715Notes

Reaction equation

HRID 1754715 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:13][CH3:14])[N:7]=[C:8]([N+:10]([O-])=O)[CH:9]=1)=[O:4]>CO>[CH3:1][O:2][C:3]([C:5]1[N:6]([CH2:13][CH3:14])[N:7]=[C:8]([NH2:10])[CH:9]=1)=[O:4]

Participants

3

Reactant 1

HCID 57619279HCID 57619279, compound

Product 1

HCID 576194165-amino-2-ethyl-2H-pyrazole-3-carboxylic acid methyl ester

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 2-ethyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester (526, 1.30 g, 6.53 mmol) in methanol (60.0 mL) was added 20% Pd(OH)2C (0.1 g). The reaction was stirred under an atmosphere of hydrogen overnight. The reaction was filtered and concentrated to give a light yellow solid (527, 1.0 g, 90.6%).

Workup

  1. filtrationThe reaction was filtered
  2. concentrationconcentrated
  3. customto give a light yellow solid (527, 1.0 g, 90.6%)

Sources & evidence

ORD record
ord-c60192df6f6f4776a19847a77d8b904a
Source dataset
uspto-grants-2015_10
Patent number
US09169250B2

Reaction notes

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