4-Bromophenacyl bromide → HCID 71677838, compound

HRID 1754811Notes

Reaction equation

HRID 1754811 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=[O:4].[O:12]1[CH:16]2[O:17][CH2:18][CH2:19][N:15]2[CH2:14][CH2:13]1>ClCCl>[Br-:1].[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][N+:15]23[CH2:19][CH2:18][O:17][CH:16]2[O:12][CH2:13][CH2:14]3)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 74544-Bromophenacyl bromideHCID 798431-Aza-4,6-dioxabicyclo(3.3.0)octane

Product 1

HCID 71677838HCID 71677838, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 2.779 g (10 mmol) 2,4′-dibromoacetophenone and 1.152 g (10 mmol) tetrahydro[1,3]oxazolo[2,3-b][1,3]oxazole in 20 ml of dichloromethane was refluxed for 3 hours. The precipitate was filtered off, washed twice with dichloromethane and dried. 3.801 g (96.7%) of white amorphous product was obtained, which can be further purified by recrystallisation from rectified ethanol.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed twice with dichloromethane
  3. customdried

Sources & evidence

ORD record
ord-e30cb60b17544e83963c0ba898633220
Source dataset
uspto-grants-2015_10
Patent number
US09169267B2

Reaction notes

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