1-(1,1'-Biphenyl)-4-yl-2-bromoethanone → HCID 71677840, compound

HRID 1754812Notes

Reaction equation

HRID 1754812 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)=[O:4].[O:17]1[CH:21]2[O:22][CH2:23][CH2:24][N:20]2[CH2:19][CH2:18]1>C(O)(C)C>[Br-:1].[C:8]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][N+:20]23[CH2:24][CH2:23][O:22][CH:21]2[O:17][CH2:18][CH2:19]3)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 672821-(1,1'-Biphenyl)-4-yl-2-bromoethanoneHCID 798431-Aza-4,6-dioxabicyclo(3.3.0)octane

Product 1

HCID 71677840HCID 71677840, compoundYield 90.2%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 2.751 g (10 mmol) 2-bromo-4′-phenylacetophenone and 1.152 g (10 mmol) tetrahydro[1,3]oxazolo[2,3-b][1,3]oxazole in 20 ml of isopropanol was refluxed for 30 minutes. The reaction mixture was allowed to cool overnight and the precipitate was then filtered off, washed twice with dichloromethane and dried. 3.520 g (90.2%) of white fine crystalline product was obtained.

Workup

  1. temperatureto cool overnight
  2. filtrationthe precipitate was then filtered off
  3. washwashed twice with dichloromethane
  4. customdried

Sources & evidence

ORD record
ord-0d5872c7f18b4c86978becb64074306a
Source dataset
uspto-grants-2015_10
Patent number
US09169267B2

Reaction notes

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