alpha-Chloro-m-nitrotoluene → HCID 71677844, compound

HRID 1754814Notes

Reaction equation

HRID 1754814 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][Cl:8])([O-:3])=[O:2].[O:12]1[CH:16]2[O:17][CH2:18][CH2:19][N:15]2[CH2:14][CH2:13]1>C(Cl)(Cl)Cl>[Cl-:8].[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][N+:15]12[CH2:19][CH2:18][O:17][CH:16]1[O:12][CH2:13][CH2:14]2)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 12078alpha-Chloro-m-nitrotolueneHCID 798431-Aza-4,6-dioxabicyclo(3.3.0)octane

Product 1

HCID 71677844HCID 71677844, compoundYield 66.1%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 1.716 g (10 mmol) 3-nitrobenzyl chloride and 1.152 g (10 mmol) tetrahydro-[1,3]oxazolo[2,3-b][1,3]oxazole in 20 ml of chloroform was stirred at the room temperature for 3 days. The precipitate was filtered off, washed twice with dichloromethane and dried. 1.894 g (66.1%) of white amorphous product was obtained, which can be further purified by recrystallisation from rectified ethanol.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed twice with dichloromethane
  3. customdried

Sources & evidence

ORD record
ord-daf769bc56514d3298c8302ef7ee5f81
Source dataset
uspto-grants-2015_10
Patent number
US09169267B2

Reaction notes

Loading…