Potassium Nitrate → 2-Amino-5-bromo-4-fluoro-6-methyl-3-nitrobenzonitrile

HRID 17551Notes

Reaction equation

HRID 17551 reaction equation
[N+:1]([O-:4])([O-])=[O:2].[K+].[NH2:6][C:7]1[C:12]([C:13]#[N:14])=[C:11]([CH3:15])[C:10]([Br:16])=[C:9]([F:17])[CH:8]=1>S(=O)(=O)(O)O>[NH2:6][C:7]1[C:8]([N+:1]([O-:4])=[O:2])=[C:9]([F:17])[C:10]([Br:16])=[C:11]([CH3:15])[C:12]=1[C:13]#[N:14]

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 541071796-Amino-3-bromo-4-fluoro-2-methylbenzonitrile

Product 1

HCID 860973752-Amino-5-bromo-4-fluoro-6-methyl-3-nitrobenzonitrile

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

With cooling with ice, potassium nitrate (2.43 g, 21.8 mmol) was gradually added to a concentrated sulfuric acid (20 ml) solution of 6-amino-3-bromo-4-fluoro-2-methylbenzonitrile (I-265) (5.00 g, 21.8 mmol). After stirring for 10 minutes, the reaction liquid was poured into ice and stirred.

Workup

  1. customthe reaction liquid
  2. additionwas poured into ice
  3. stirringstirred

Sources & evidence

ORD record
ord-95eefb43a22349c2885c61ec4eb100ed
Source dataset
uspto-grants-2010_06
Patent number
US07737166B2

Reaction notes

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