反应详情

4-{[(4-tert-Butyl-phenyl)-(4-iodo-phenylcarbamoyl)-methyl]-amino}-benzoic acid tert-butyl ester (430 mg, 0.74 mmol) was taken up in 10 mL of dichloromethane followed by addition of 1 mL of TFA and stirred for 16 h at RT. Removal of the organic layer under reduced pressure followed by addition of water to the precipitate. The solids were filtered to give 340 mg (87%) of white solids. 1H NMR showed the compound to be very clean and sufficient for the following step. LCMS (M+1=529.6).

1. customRemoval of the organic layer under reduced pressure
2. additionfollowed by addition of water to the precipitate
3. filtrationThe solids were filtered