Hydrochloric Acid → HCID 75204201, compound

HRID 1755241Notes

Reaction equation

HRID 1755241 reaction equation
[C:1]1([N:10]2[CH2:14][CH2:13][C@H:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11]2)[C:2]2[N:3]([CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:5][N:6]=1.Cl>O1CCOCC1>[C:1]1([N:10]2[CH2:14][CH2:13][C@H:12]([NH2:15])[CH2:11]2)[C:2]2[N:3]([CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86720533HCID 86720533, compound

Product 1

HCID 75204201HCID 75204201, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
60 °C

Procedure

To a solution of (S)-tert-butyl N-(1-(pyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl)carbamate (0.88 g, 2.9 mmol, 1 eq) in 3.6 mL of dioxane was added a solution of 4.0 M HCl in dioxane (3.6 mL, 14.5 mmol, 5 eq). After heating for 1 h at 60° C., the mixture was concentrated to afford (S)-1-(pyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-amine (0.79 g, 2.9 mmol, 100%).

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-97480de863aa4b918a29e65a4c7b0032
Source dataset
uspto-grants-2015_10
Patent number
US09169261B2

Reaction notes

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