Hydrochloric Acid → HCID 86720538, compound

HRID 1755249Notes

Reaction equation

HRID 1755249 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]([NH:14][C@H:15]1[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16]1)=[O:13])[N:6]=[CH:5]2.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]([NH:14][C@H:15]1[CH2:19][CH2:18][NH:17][CH2:16]1)=[O:13])[N:6]=[CH:5]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86720537HCID 86720537, compound

Product 1

HCID 86720538HCID 86720538, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
60 °C

Procedure

To a solution of (S)-tert-butyl 3-(6-chloroquinazoline-2-carboxamido)pyrrolidine-1-carboxylate (0.086 g, 0.23 mmol, 1 eq) in 1 mL of p-dioxane was added a solution of 4.0 M HCl in dioxane (0.29 mL, 1.2 mmol, 5 eq). After stirring at 60° C. for 1 h, the mixture was concentrated to provide (S)-6-chloro-N-(pyrrolidin-3-yl)quinazoline-2-carboxamide which was carried on without further purification.

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-52eb8685d79d44299aee17a35545373d
Source dataset
uspto-grants-2015_10
Patent number
US09169261B2

Reaction notes

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