Benzylamine → 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione

HRID 1755325노트

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HRID 1755325 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:9]12[CH2:14][CH:13]1[C:12](=[O:15])N[C:10]2=[O:16]>>[CH2:1]([N:8]1[C:12](=[O:15])[CH:13]2[CH:9]([CH2:14]2)[C:10]1=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 7504BenzylamineHCID 37200533-Azabicyclo[3.1.0]hexane-2,4-dione

생성물 1

HCID 27645863-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione수율 83%

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온도
170 °C

실험 절차

Benzylamine (2.5 mL, 22.3 mmol) was added drop wise to ice cooled 3-aza-bicyclo[3.1.0]hexane-2,4-dione (2.5 g, 22.3 mmol) then the mixture was heated to 170° C. with stirring for 1.5 h. After cooling to room temperature, the resulting mixture was crystallized from isopropanol to give 3-benzyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione (3.72 g, 83%) as a white solid. LC-MS: [M+H]+, 202.1, tR=1.478 min.

후처리

  1. temperatureAfter cooling to room temperature
  2. customthe resulting mixture was crystallized from isopropanol

출처 및 근거

ORD 기록
ord-f0c8ce78ca0043fdb0a42f18d21d5dc3
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09169259B2

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