HRID1755407
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 25 °C
PROCEDURE
实验过程
A suspension of tert-butyl 1-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)pyrrolidin-3-ylcarbamate (180 mg, 0.40 mmol) and TFA (2 mL) in dichloromethane (5 mL) was stirred at 25° C. for 6 h. The residue was concentrated to give 6-(3-aminopyrrolidin-1-yl)-N-(5,6-dimethoxypyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine (180 mg, crude) as a red liquid. This was used directly without purification. LC-MS: 356 [M+1]+, tR=1.187 min.
WORKUP
后处理
- concentrationThe residue was concentrated