HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (S)-2-(5-Formylthiazol-2-ylamino)-3-methylbutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-tert-Butyl 2-(5-formylthiazol-2-ylamino)-3-methylbutanoate | HCID 131733674 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-2-(5-Formylthiazol-2-ylamino)-3-methylbutanoic acid | HCID 89858211 | 200.1% |
Reaction Steps
Following the procedure described in Example 3, except using the material from Example 19 (2.99 g, 10.51 mmol), CH2Cl2 (200 mL) and TFA (51 mL, 662 mmol), 4.8 g (quantitative yield) of the title compound is obtained as a tan syrup as a bis TFA salt. LC/MS (Condition A): ret. T=2.33 min, (M+H)+ 229.04.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09169295B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-eddbc34c4eba495ebb8737e9a197f1a7 |
| Source note | uspto-grants-2015_10 |