Trifluoroacetic acid → HCID 86700122, compound

HRID 1755477Notes

Reaction equation

HRID 1755477 reaction equation
[CH:1]([C:3]1[S:7][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:46])[C@H:14]([CH3:45])[NH:15][C:16](=[O:44])[C@H:17]([CH3:43])[NH:18][C:19](=[O:42])[C@H:20]([CH3:41])[NH:21][C:22](=[O:40])[C@@H:23]([NH:32]C(=O)OC(C)(C)C)[CH2:24][C:25]2[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=2)=[N:5][CH:4]=1)=[O:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:32][C@@H:23]([CH2:24][C:25]1[CH:26]=[CH:27][C:28]([OH:31])=[CH:29][CH:30]=1)[C:22]([NH:21][C@@H:20]([CH3:41])[C:19]([NH:18][C@@H:17]([CH3:43])[C:16]([NH:15][C@@H:14]([CH3:45])[C:13]([NH:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]1[S:7][C:3]([CH:1]=[O:2])=[CH:4][N:5]=1)=[O:46])=[O:44])=[O:42])=[O:40]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86700116HCID 86700116, compound

Product 1

HCID 86700122HCID 86700122, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the procedure as described in Example 3, except using material from Example 75 (100.2 mg, 0.129 mmol), CH2Cl2 (2 mL), TFA (2 mL, 26 mmol) and stirring at room temp for 2 h, the title compound (quantitative yield) is isolated as an off white solid, as a TFA salt, that is used directly “as is” in the next coupling step. LC/MS (Condition A): ret. T=1.88 min, (M+H)+ 562.37.

Sources & evidence

ORD record
ord-ec9078e697b3457d9caaaa3d8755f52a
Source dataset
uspto-grants-2015_10
Patent number
US09169295B2

Reaction notes

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