反应详情

9.3 g of the compound (2), 4.0 g of potassium hydroxide and 1 ml of water were dissolved in methanol, and reflux was carried out for one hour. After addition of 50 ml of water, reflux was further carried out for three hours. The reaction mixture was adjusted to pH 2 by adding diluted hydrochloric acid. The precipitate was collected by filtration and was then washed with water, to obtain 8.1 g of the objective compound (3). (Yield: 90%)

1. temperaturereflux
2. temperaturereflux
3. waitwas further carried out for three hours
4. filtrationThe precipitate was collected by filtration
5. washwas then washed with water