Hydrochloric Acid → HCID 19917647, compound

HRID 1755607Notes

Reaction equation

HRID 1755607 reaction equation
[CH2:1]=[CH:2][CH:3]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=1)[CH2:4][CH:5]=[CH2:6].[OH-].[K+].O.Cl>CO>[CH2:1]=[CH:2][CH:3]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([C:23]([OH:25])=[O:24])=[CH:27][CH:28]=1)[CH2:4][CH:5]=[CH2:6]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962Water2×HCID 14797Potassium HydroxideHCID 19917653HCID 19917653, compound

Product 1

HCID 19917647HCID 19917647, compoundYield 90.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

9.3 g of the compound (2), 4.0 g of potassium hydroxide and 1 ml of water were dissolved in methanol, and reflux was carried out for one hour. After addition of 50 ml of water, reflux was further carried out for three hours. The reaction mixture was adjusted to pH 2 by adding diluted hydrochloric acid. The precipitate was collected by filtration and was then washed with water, to obtain 8.1 g of the objective compound (3). (Yield: 90%)

Workup

  1. temperaturereflux
  2. temperaturereflux
  3. waitwas further carried out for three hours
  4. filtrationThe precipitate was collected by filtration
  5. washwas then washed with water

Sources & evidence

ORD record
ord-4e3d4c3e856147eaa7c65acbed1f80da
Source dataset
uspto-grants-1995_08
Patent number
US05437816

Reaction notes

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